December 2025 Supplement of the Month: Phosphatidylserine

Nov 17, 2025

Supplement Spotlight: Phosphatidylserine (PS)

This month, we are focusing on a remarkable nutrient that helps balance your body’s response to stress: Phosphatidylserine, commonly called PS.

What is PS?

Phosphatidylserine is not a vitamin or a mineral; it is a naturally occurring fatty compound, or phospholipid, that is a core structural component of every cell membrane in your body, especially those in your brain. It is vital for maintaining the health and communication pathways of your nerve cells.

PS and Cortisol Control

The primary reason we utilize PS in functional medicine is its unique ability to moderate the stress response. When you are under chronic stress, your adrenal glands flood your system with the hormone cortisol. PS works by helping to regulate the HPA axis—the body’s central stress feedback loop—to efficiently tell your body to "stand down" after a stressful event. By helping to lower prolonged, elevated cortisol levels, PS contributes to better sleep, improved mood, and reduced feelings of constant anxiousness.

Support for Focus and Memory

Beyond stress management, PS is a powerful neuro-nutrient. Because it is so highly concentrated in the brain, ensuring adequate levels supports:

• Cognitive Function: Sharper focus and better concentration.

• Memory: Improved ability to recall information and enhance learning.

When to Consider PS

PS is often recommended strategically, particularly for individuals dealing with chronic, mild to moderate anxiety, periods of high stress or burnout, and those looking for natural support for cognitive sharpness as they age.

As always, consult with your practitioner to determine the correct dosage and ensure it aligns with your specific health goals.

(Disclaimer: This is for informational purposes only and is not a substitute for professional medical advice. Always consult with your healthcare provider before starting any new supplement.)